Week 10 Fantasy Matchups: Key Players to Start and Sit

The fantasy football playoff push is heating up, and Week 10 brings some critical matchups that could make or break your season. With bye weeks behind us and the trade deadline approaching, it's time to optimize your lineups based on matchup data and game flow projections.

Top Passing Matchups

Ravens vs. Bengals (+88.6%)

This AFC North showdown features the best passing matchup of the week. Both defenses have struggled against the pass, making this a potential shootout.

Fantasy Impact:

• Lamar Jackson returns to elite QB1 status after his injury recovery
• Joe Burrow remains a top-tier streaming option
• Wide receivers on both sides (Ja'Marr Chase, Zay Flowers) see increased value

Vikings at Jaguars (+75.7%)

Minnesota's offense continues to roll, and Jacksonville's secondary has been one of the league's most generous to opposing passers.

Start With Confidence:

• Justin Jefferson - WR1 upside with excellent target share
• Jordan Addison - Flex play with TD potential
• T.J. Hockenson - Top-5 TE this week

Bills at Colts (+57.7%)

Buffalo's passing attack faces a Colts defense that's been exploitable through the air. Josh Allen continues his MVP-caliber season.

Key Players:

• Josh Allen - QB1 with rushing upside
• Stefon Diggs - Lock for 7+ targets
• Dawson Knox - Streaming TE option

Fastest-Paced Games to Target

Game pace matters for fantasy production. Here are the Week 10 games projected for the most plays:

1. Falcons at Saints (25.3 seconds)

This NFC South rivalry typically produces fast-paced, high-volume games.

Volume Plays:

• Bijan Robinson - 20+ touches expected
• Chris Olave - High-floor WR2
• Drake London - Coming back from injury, monitor status

2. Bills at Colts (25.7 seconds)

Buffalo's tempo offense creates opportunities for both teams' skill players.

3. Patriots at Bears (26.1 seconds)

Despite struggling offenses, both teams play at an above-average pace.

Sneaky Starts:

• D.J. Moore - Target monster in PPR
• Cole Kmet - Bengals' defense is TE-friendly

Key Lineup Decisions

Start 'Em

Running Backs:

• Jonathan Taylor (vs BUF) - Despite tough matchup, volume is king
• James Cook (@ IND) - Explosive plays and goal-line work
• De'Von Achane (vs LV) - Speed kills on fast track

Wide Receivers:

• Tyreek Hill (vs LV) - Always start your studs
• Amon-Ra St. Brown (vs LAC) - Target share machine
• Brandon Aiyuk (@ JAX) - Bounce-back spot

Tight Ends:

• Travis Kelce (vs DEN) - Target spike continues
• Evan Engram (vs MIN) - Home matchup, PPR value

Sit 'Em

Running Backs:

• Ezekiel Elliott (@ NYG) - Limited upside in committee
• Gus Edwards (@ LV) - Touchdown-dependent

Wide Receivers:

• Marquise Brown (vs MIA) - Inconsistent target share
• Tyler Lockett (vs WSH) - Boom-or-bust WR3/4

Defense/Special Teams Streamers

Looking for a Week 10 DST play? Target these units:

1. Buffalo Bills (@ IND) - Gardner Minshew prone to turnovers
2. Pittsburgh Steelers (@ WSH) - Sam Howell under pressure
3. Cleveland Browns (vs ARI) - Joshua Dobbs revenge game narrative, but Browns D elite

Weather Watch

No significant weather concerns for Week 10. All games forecast for playable conditions with minimal wind or precipitation impact.

The Bottom Line

Week 10 is about exploiting favorable matchups while maintaining roster construction for the playoff push. Don't get cute with your studs, but look for streaming opportunities in the passing game against Baltimore and Cincinnati's vulnerable secondaries.

Pro Tip: Monitor injury reports closely, especially for players like Drake London who are returning from multi-week absences. Practice participation Wednesday and Thursday will be critical for final lineup decisions.

Good luck in Week 10, and may your matchups be favorable!